Advancements in RNA 2’-OH Covalent Modification with Reactive Small Molecules
9:30 am - Thursday 10th December 2026
- Introduce RNA 2’-OH modification as a versatile post-synthetic conjugation strategy for oligonucleotides that can go beyond what is possible with standard solid-phase oligonucleotide synthesis
- Describe the chemical classes that can drive these reactions, their advantages/disadvantages, and how they may be manufactured
- Applications of this technology to oligonucleotide stability enhancement, delivery, and structure analysis, and where future work may lead to effective drug development
