Assessing & Improving Specificity of Therapeutic siRNAs in Preclinical Models
Time: 4:00 pm
day: Conference Day One
Details:
- Review how small chemical tweaks can dramatically improve target engagement and hybridization kinetics
- Unpack the structural features that drive binding specificity and reduce unwanted interactions with non-target transcripts
- Explore screening methods and predictive tools to de-risk oligo designs before clinical translation