Assessing & Improving Specificity of Therapeutic siRNAs in Preclinical Models

• Review how small chemical tweaks can dramatically improve target engagement and hybridization kinetics
• Unpack the structural features that drive binding specificity and reduce unwanted interactions with non-target transcripts
• Explore screening methods and predictive tools to de-risk oligo designs before clinical translation

Speakers:

Utsav Saxena

Head of Systems Biology

Novo Nordisk