Modulation of the Tumor Microenvironment Using Antisense Oligonucleotides

Time: 11:30 am
day: Conference Day One

Details:

• Tumors actively shape their microenvironment to promote angiogenesis, metastasis, and immune evasion, creating conditions that support their growth and resistance to therapy
• Neuropilin-1 (NRP1) is broadly expressed across multiple cell types within the tumor microenvironment, where it simultaneously facilitates these pro-tumorigenic processes
• Antisense oligonucleotides (ASOs) designed to silence NRP1 expression effectively reduce its levels in key cellular compartments, leading to potent antitumor activity both as a monotherapy and in combination with immune checkpoint inhibitors

Speakers:

Frank Jaschinski Frank joined Secarna in 2015 as its Chief Scientific Officer. He is an expert in the discovery and development of antisense oligonucleotides. Frank’s therapeutic expertise Read more