Alfica Sehgal
Chief Scientific Officer Judo Bio
Seminars
Tuesday 8th December 2026
Building the Next Generation of Conjugates, Ligands & Linkers for Targeted Oligonucleotide Delivery to Unlock Extrahepatic Tissues & Improve Therapeutic Efficacy
Interactive workshop exploring how developers are designing, selecting and optimizing conjugates, ligands and linkers to improve tissue-specific delivery and maximize therapeutic performance. Through expert discussion and practical case studies, attendees will evaluate the critical design decisions that influence target efficiency, manufacturability, safety and long-term platform potential.
Workshop highlights
- Evaluate the latest ligand discovery strategies, comparing established targets such as ASGPR and transferrin receptor with emerging receptor biology to identify new opportunities for tissue-specific delivery
- Explore how linker design influences conjugate performance, understanding the impact of stability, release mechanisms and pharmacokinetics on efficacy, safety and therapeutic index
- Understand the CMC and manufacturing considerations that shape successful conjugate development, including process scalability, raw material selection, technology transfer and the impact of design decisions on manufacturability and clinical supply
- Leave with a practical framework for building a competitive targeting platform, including the key scientific, translational and commercial questions partners and investors will expect your technology to answer before advancing into collaboration or development
