Paloma Giangrande

Company: Orbital Therapeutic

Job title: Senior Vice President - Discovery & Translational Biology

Bio:

Dr. Paloma Giangrande is an internationally recognized expert in nucleic acid therapeutics and delivery. She pioneered the use of RNA aptamers for targeted siRNA delivery beyond the liver, significantly expanding the therapeutic potential of RNA interference. She has held key leadership roles in renowned biotechnology companies, including as Director of Rare Diseases at Moderna, where she spearheaded mRNA therapeutic programs for rare genetic diseases; as Vice President of Platform Biology at Wave Life Sciences, where she led the groundbreaking RNA Editing program to a first-in-human stage, and as Chief Technology Officer at Eleven Therapeutics, where she drove the strategic direction for the company’s core xRNA technologies and platforms. Her strategic leadership at prestigious institutions underscores her commitment to advancing innovative RNA-based treatments.

Seminars:

Leveraging Delivery Approaches to Translate Oligonucleotide-Based Therapies for Different Indications 9:05 am

The success of oligonucleotide therapeutics hinges not only on target selection and chemistry but also on delivery strategies that can unlock extrahepatic targets and expand the reach of these modalities. While conjugate-based approaches have driven remarkable progress in hepatocyte delivery, new indications, from neuromuscular diseases to oncology, demand innovative delivery solutions to overcome biological barriers,…Read more

day: Pre-Conference Workshop Day