Qian Chen
Founder - Scientific NanoDe Therapeutics
Dr. Qian Chen is the Michael G. Ehrlich, MD Endowed Chair in Orthopaedic Research, Professor of Medical Science, and Vice Chair for Research in the Department of Orthopaedics at the Warren Alpert Medical School of Brown University. He is the Director of Scientific Advisory Board of NanoDe Therapeutics, a pre-clinical stage company developing non-viral, non-lipid delivery for nucleic acid therapeutics.
Seminars
Thursday 10th December 2026
Interrogating the Depot Effect & Accumulation of siRNAs & ASOs to Improve Safety, Enable Sustained Release & Extend Dosing Intervals
1:45 pm
- Understand why certain tissues can accumulate high levels of siRNA and ASOs while showing limited or no measurable gene silencing activity
- Explore how to distinguish productive versus unproductive intracellular trafficking pathways and identify the factors that determine functional delivery
- Examine emerging approaches to rescue oligonucleotides trapped in non-productive pathways, including dual-receptor strategies and next-generation delivery innovations
