Steve Dowdy
Professor University of California, San Francisco
Seminars
Thursday 10th December 2026
Endosomal Escape The Field’s Rate-Limiting Step in Unlocking Oligonucleotide Potency
2:45 pm
- Gain insights from a leading researcher in endosomal escape on why overcoming this barrier remains a central challenge for the next generation of oligonucleotide therapeutics
- Understand the mechanistic gap between cellular uptake and functional cytosolic delivery, including why many internalised oligonucleotides fail to reach their intended site of action
- Evaluate emerging endosomal escape strategies and distinguish approaches showing genuine promise from those that remain early-stage or speculative
