Endosomal Escape The Field’s Rate-Limiting Step in Unlocking Oligonucleotide Potency

• Gain insights from a leading researcher in endosomal escape on why overcoming this barrier remains a central challenge for the next generation of oligonucleotide therapeutics
• Understand the mechanistic gap between cellular uptake and functional cytosolic delivery, including why many internalised oligonucleotides fail to reach their intended site of action
• Evaluate emerging endosomal escape strategies and distinguish approaches showing genuine promise from those that remain early-stage or speculative

Speakers:

Steve Dowdy

Professor

University of California, San Francisco