Interrogating the Depot Effect & Accumulation of siRNAs & ASOs to Improve Safety, Enable Sustained Release & Extend Dosing Intervals
1:45 pm - Thursday 10th December 2026
- Understand why certain tissues can accumulate high levels of siRNA and ASOs while showing limited or no measurable gene silencing activity
- Explore how to distinguish productive versus unproductive intracellular trafficking pathways and identify the factors that determine functional delivery
- Examine emerging approaches to rescue oligonucleotides trapped in non-productive pathways, including dual-receptor strategies and next-generation delivery innovations
